Disease Models

BTS Research CRO offers world class preclinical study applications that can help you achieve your study disease model. Many of our disease models have in house data that can be readily shared with clients upon request. If the disease model that you are looking for is not listed, there is still a very good possibility that we can do it for you, and in many cases, BTS Research will help you proof design the disease model at no extra charge.

Some of our most recent validated disease models include:

  • Rabbit Wessler Model of Thrombosis.
  • Mouse Model of Contact Hypersensitivity.
  • Acute Mouse Model of CCL4 Liver Fibrosis.
  • Imiquimod (IMQ) Induced Psoriasis in BALB/c Mice.

In case your disease model requires development or is not listed, there is still a very good possibility that we can do it.

Oncology Models

BTS Research offers world class preclinical study applications that can help you in implementing your research in your desired study disease model. Not all of our disease models and in house data are published on the website so if the disease model or the in house data that you are looking for is not listed, click here to receive more information.

BTS Research has over 350 xenografts cell lines, from which over 100 xenografts have been validated. We offer standard and unique animal model studies including but not limited to immune compromised Athymic nude mouse, SCID/Beige mouse and NOD/SCID mouse. As well as non-immune compromised C57BL/6 mouse.

We offer standard and unique animal model studies, including:

  • Tumor Implants
  • Human xenografts in nude athymic mice
  • Orthotopic and ectotopic implantation
  • Leukemia models (NOD/SCID)
  • Induced Metastasis Models
  • Orthotopic and footpad implantation
  • Xenograft in Humanized Mice
  • Syngeneic Tumor Models

Immune and Inflammatory Disease Models

Having done hundreds of studies in these models, BTS Research can be considered an expert in many of the following models.

Arthritis

  • CIA (collagen induced arthritis)
  • SCW Streptococcal Cell Wall Arthritis
  • Mouse Adjuvant Arthritis
  • Cytokine Analysis, Histopath, X-ray analysis, Joint Swelling

Chronic Joint Inflammation

  • Mouse Type II Collagen (CIA) and SCW Arthritis
  • Mouse Adjuvant Arthritis
  • Cytokine Analysis, Histopath, X-ray analysis, Joint Swelling

Acute Paw Inflammation

  • Mouse Carrageenan and Oxazolone Paw Edema
  • Mouse Zymosan Paw Edema
  • Cytokine Analysis

Acute Air Pouch Inflammation

  • Mouse & Rat (Carrageenan, Chemoattractant, TNF-a, IL-1b, Superantigens)
  • Cytokine Analysis, Cell Number, and Cell Phenotyping (Cytospin & FACS)

Acute Inflammation

  • Mouse LPS-induced inflammation (local and systemic)
  • Mouse LPS/D-Gal-induced mortality
  • Cytokine Analysis

Acute Rhinitis moduleDermal Irritation (Draize Modified Scoring)Systemic InflammationDelayed Type Hypersensitivity (DTH)

  • Mouse air pouch model with chemoattractants, superantigens, and toxins
  • Mouse intraperitoneal migration model with Chemokines, superantigens, toxins and Oxazolone
  • Mouse and Minipig Th1 and Th2 DTH and ACD skin migration model
  • Cytokine Analysis, Cell Migration, Ex Vivo Cell Proliferation

 

Monosodium-Urate (MSU) crystals induced mouse neutrophil migration

  • Mouse air pouch model with chemoattractants, superantigens, and toxins
  • Mouse intraperitoneal migration model with Chemokines, superantigens, toxins and Oxazolone
  • Mouse and Minipig Th1 and Th2 DTH and ACD skin migration model
  • Cytokine Analysis, Cell Migration, Ex

Chronic CNS Inflammation

  • Mouse Experimental-Induced Encephalomyelitis (EAE) (Acute B6 Mice, SJL, Biozzi Mice)
  • Spontaneous EAE mouse B6/RAG/TR model
  • Cytokine Analysis, Cell Proliferation

Gastrointestinal Inflammation/Irritation (colitis models)

  • Colonic Inflammation: Mouse Dextran Sulfate and Oxazolone Models
  • Acute Gastric Irritation in mice (4 hr)
  • 3-day Intestinal Irritation in mice (72 hr)
  • Cytokine Analysis, colon assessment and histopath

Asthma and COPD

  • Mouse Ovalbumin asthma model
  • Mouse Cockroach asthma model
  • Mouse PPE induced COPD
  • Smoke induced COPD
  • Cytokine Analysis, cell differential count in broncho-alveolar lavages

Liver and lung fibrosis models

  • Liver fibrosis (CCL4 and DNFB induced) and Lung fibrosis (Belomycin induced)

Mouse Ovalbumin asthma model/Dermatitis models

  • Atopic dermatitis in NcNGA transgenic mice
  • DNFB induced dermatitis in mice and pigs
  • Engraftment of human Psoriatic skin in mice
  • IL-12/lps-induced human like psoriasis in scid mice

Diabetes Type 1 and 2

We provide different types of diabetic models in small and large animals. Please contact us for information about your specific study design requirements.

  • Mouse
  • Rat
  • MiniPig

Wound Healing

With many models designed in house, BTS Research has performed hundreds of wound healing studies and has many models established. BTS Research offers a vast array of expertise in wound healing which can be readily available to our clients or can be used to support your specific dermal study needs.

  • Mice
  • Rat
  • MiniPig (deep wounds, long term)

Central Nervous System

BTS Research core competency in the area of CNS is based on IND enabling study requirements.

  • Behavioral Screening Open Field
  • Morris Water Maze
  • Paw Strength (Front or back limps)
  • Roto-Rod
  • Epilepsy

The following models can be performed:

    Neurodegeneration

  • Parkinson’s
  • Huntington’s
  • Alzheimer’s
  • Epilepsy
  • Spinal Cord Injury
  • Glioblastoma
  • Custom CNS Models

 

    Behavioral Screening

  • Open Field Activity
  • Morris Water Maze
  • Roto-Rod
  • Beam Walk
  • Rotometer
  • Paw Placing

Various Models

Some of the models that BTS Research has established are listed below. If your disease model is not listed, feel free to contact us to discuss our abilities as we are always expanding our capabilities.

  • Acute and chronic CCl4 and DMN liver fibrosis (mice, rats)
  • Acute or chronic-repeated short and long term infusion/dosing
  • ADME
    ADME – NHP, Rodent, Dog, Pig
  • Air pouch
  • Air pouch model on rats (inflamation)
  • Antibody production
  • Asthma Ovalbumin Induced
  • Bile duct cannulated colony
  • Blader manipulation
  • Brain receptor occupancy: Mouse, Rat
  • Brain receptor occupancy: Rat
  • Calvarial defect: Rat
  • Canulated rat infusion PK
  • Cardiovascular
  • Cecal Ligation
  • Cecal ligation: Rat
  • CIA on murine
  • CLP-induced sepsis
  • CNS (some models)
  • Colitis
  • Colitis DSS induced
  • Collagen Induced Arthritis CIA
  • Contact hypersensitivity (~ delayed type hypersensitivity)
  • COPD Elastase-Collagenase and smoke induced.
  • db/db mouse dermal wound
  • Dermatitis
  • Diabetic
  • Diabetic models on rats and pigs
  • Diet-induced obesity (< 6 months)
  • Diet-induced type II diabetes
  • DIO feeding study: Mouse
  • Dorsal and ventral spinal nerve electrophysiology
  • DTH Oxazalone and DNFB induced
  • DTH on murine and pigs
  • EAE (experimental autoimmune encephalomyelitis)
  • EAE MOG + PT induced
  • EAE PLP induced
  • EAE on murine
  • Full thickness dermal wound healing: Rabbit
  • Functional Observational Battery
  • Gastric emptying
  • Genetic models of obesity (mouse and rat)
  • Genetic models of type II diabetes (mouse and rat)
  • Hepatic fibrosis CCl4 induced
  • Hepatic fibrosis DMN induced
  • Hollow fiber cell assay: Mouse
  • Infection Model (E. Coli and S. Aureus resistant strains)
  • Insulin tolerance test (IP)
  • Insulin tolerance test (IV)
  • Intra Occular Pressure measurements
  • Kidney Disease
  • IV dose MOLT4 for leukemia model
  • IV injection of labeled-neutrophils in rabbits and assessing chemokine-mediated migration

 

  • Laser Doppler blood flow
  • Liver Disease
  • Liver perfusion (Cardiac flush and Infusion pump flush)
  • LPS and Galactosamine inflamation model
  • LPS lethality
  • Lung inflamation model, cockroach antigen
  • Lung Metastasis (ie. B16-F10)
  • Lupus model
  • Mass balance
  • Models of hyperlipidemia
  • Mouse OVA asthma
  • Mouse xenograft models
  • Neurotox Testing Batteries
  • Obesity
  • Ocular
  • Occular and opthalmic models
  • Oral glucose tolerance test
  • Organ cell inoculation (liver and kidney)
  • Orthotopic and ectopic bone healing: Rabbit
  • Orthotopic and ectopic bone healing: Rat
  • OxyMax calculation of fatty acid and carbohydrate oxidation rates
  • OxyMax open calorimetry system (acute and sub-chronic)
  • Parkinson’s
  • Passive cutaneous anaphylaxis
  • Patch application
  • Peripheral nerve electrophysiology
  • PK
  • Pulmonary and hepatic fibrosis: Mouse
  • Pulmonary/hepatic fibrosis: Rat
  • Radiation Exposure
  • Rat adrenalectomy
  • Rat ICV studies
  • Rectus muscle pouch: Rat
  • Repeated long term IV infusion
  • Rodent dermal inflammation
  • Rodent models of diabetes (type I and type II)
  • Rodent vascular permeabilty
  • Rotarod
  • Smoke inhalation in mice
  • Spinal ligation: Rat
  • Spinal surgeries
  • Stem Cell
  • Sterotaxis
  • Stifle joint injection and aspiration of sinovial fluid: Dog
  • Stroke
  • Subcutaneous pouch: Rat
  • TNF +/- galactosamine lethality
  • Tox – small and large animal with daily dosing
  • Ulna defect model (long bone): Rabbit
  • Vein graft (femoral artery/vein): Rat
  • Von Frey hair sensory testing
  • Water maze
  • Wound healing Model on rats and Pigs
  • Wound healing with laser Doppler testing
  • Xenograph Tumor Models

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All testing complies with applicable Good Laboratory Practice (GLP) regulations. We are committed to excellent client service and appreciate the opportunity to discuss your testing requirements.

BTS Research is a San Diego based Contract Research Organization that delivers GLP and Non-GLP biological services to clients in pharmaceutical/biopharmaceutical, biotech, academic research, medical device and related industries since 2001.